STUDY DESIGN AND RATIONALE OF EXPLORER-CN: A PHASE III, RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFICACY AND SAFETY OF MAVACAMTEN IN CHINESE ADULTS WITH SYMPTOMATIC OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY

Introduction Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease commonly caused by pathogenic genetic variants encoding sarcomere proteins.Mavacamten, a first-in-class allosteric inhibitor of cardiac-specific myosin, has demonstrated efficacy and safety in international clinical trials of patients with symptomatic obstructive HCM (oH

Fatigue in any material is a result of continuous irreversible degradation process.Traditionally, fatigue life is predicted by click here extrapolating experimentally curve fitted empirical models.In the current study, unified mechanics theory is used to predict life of Ti-6Al-4V under monotonic tensile, compressive and cyclic load conditions.The u

Margarite- and muscovite-bearing pseudomorphs after topaz are described from the Juurakko pegmatite dyke, Orivesi, southern Finland.A supercritical vapour phase rich in calcium and alkalies caused alteration of topaz and some other silicates during final phase of crystallization of the dyke.The original columnar form of topaz crystals is characteri